Interaction between Fokl polymorphism and vitamin D deficiency in the symptoms of mental disorders in adults: a population-based study.

Mental disorders are intricate and multifaceted and encompass social, economic, environmental, and biological factors. This study aimed to explore the potential association between vitamin D deficiency and anxiety and depression symptoms in adults, considering the role of the vitamin D receptor gene polymorphism FokI (rs2228570). This was a population-based cross-sectional study with stratified and cluster sampling, evaluating anxiety symptoms (AS) and depression symptoms (DS) in 1637 adults. Vitamin D levels were measured using electrochemiluminescence and were considered deficient when < 20 ng/mL in a healthy population or < 30 ng/mL in at-risk groups. Genotyping was performed using real-time polymerase chain reaction with TaqMan probes. The prevalence rates of AS, DS, and vitamin D deficiency were 23.5%, 15.8%, and 30.9%, respectively. No direct association was observed between vitamin D deficiency and AS or DS. However, interaction analysis revealed a combined effect of vitamin D deficiency and FokI for DS but not for AS. Individuals with vitamin deficiency and one or two copies of the altered allele of the FokI exhibited a higher prevalence of DS than individuals homozygous for the wild-type allele and vitamin D sufficiency. The interaction between vitamin D deficiency and the FokI polymorphism was associated with DS.

[Not Available]. / Vaspin association with insulin resistance is related to physical activity and body fat in Brazilian adolescents - A cross-sectional study.

BACKGROUND: Vaspin is a newly-identifi ed adipocytokine associated with insulin resistance (IR). OBJECTIVE: The aim of this study was to investigate the correlation between plasma vaspin concentrations and IR and determine whether this association is affected by body composition, physical activity and pubertal stage in adolescents. METHODS: Were studied 484 Brazilian adolescents aged 10-14 years whose anthropometric, clinical, biochemical, and lifestyle measurements were analized. We evaluated the correlation between vaspin and risk factors for IR in adolescents with normal and high body fat percentage (%BF) and did a logistic regression to calculate the odds ratio for IR according to vaspin quartiles sex specifi c for the sample. RESULTS: Vaspin was positively correlated with IR in adolescents with high %BF (r = 0.23, p = 0.003). The logistic regression analysis adjusted for sex, age, BMI, and pubertal stage showed that adolescents in the 2nd (OR = 0.43, 95% CI = 0.23-0.80, p = 0.008) and 3rd (OR = 0.46, 95% CI = 0.25-0.85, p = 0.014) quartile of vaspin concentration had a lower risk for IR. When the model was adjusted for %BF and physical activity, the association remained statically signifi cant only for adolescents in the 2nd quartile. CONCLUSION: Vaspin was correlated positively with risk factors associated with insulin metabolism in adolescents with high %BF. Vaspin was associated with a reduced risk of IR independently of BMI and pubertal stage and the association was infl uenced by body fat and physical activity in these adolescents.

Vaspin association with insulin resistance is related to physical activity and body fat in Brazilian adolescents - A cross-sectional study / La asociación de la vaspina con la resistencia a la insulina está relacionada con la actividad física y la grasa corporal en adolescentes brasileños. Un estudio transversal

Background: Vaspin is a newly-identified adipocytokine associated with insulin resistance (IR). Objective: The aim of this study was to investigate the correlation between plasma vaspin concentrations and IR and determine whether this association is affected by body composition, physical activity and pubertal stage in adolescents. Methods: Were studied 484 Brazilian adolescents aged 10-14 years whose anthropometric, clinical, biochemical, and lifestyle measurements were analized. We evaluated the correlation between vaspin and risk factors for IR in adolescents with normal and high body fat percentage (%BF) and did a logistic regression to calculate the odds ratio for IR according to vaspin quartiles sex specific for the sample. Results: Vaspin was positively correlated with IR in adolescents with high %BF (r = 0.23, p = 0.003). The logistic regression analysis adjusted for sex, age, BMI, and pubertal stage showed that adolescents in the 2nd (OR = 0.43, 95% CI = 0.23-0.80, p = 0.008) and 3rd (OR = 0.46, 95% CI = 0.25-0.85, p = 0.014) quartile of vaspin concentration had a lower risk for IR. When the model was adjusted for %BF and physical activity, the association remained statically significant only for adolescents in the 2nd quartile. Conclusion: Vaspin was correlated positively with risk factors associated with insulin metabolism in adolescents with high %BF. Vaspin was associated with a reduced risk of IR independently of BMI and pubertal stage and the association was influenced by body fat and physical activity in these adolescents (AU)

Introducción: la vaspina es una adipocitoquina recientemente identificada que confiere resistencia a la insulina (IR). Objetivo: el objetivo de este estudio fue investigar la correlación entre las concentraciones plasmáticas de vaspina y la IR para determinar si esta asociación se ve afectada por la composición corporal, la actividad física y la etapa de la pubertad en los adolescentes. Métodos: fueron analizados las medidas antropométricas, clínicas, bioquímicas y el estilo de vida de 484 adolescentes brasileños de entre 10 y 14 años. Se evaluó la correlación entre los factores de riesgo para vaspina e IR en los adolescentes con porcentaje de grasa corporal normal y alto (%CG) e hicimos una regresión logística para calcular el cociente de probabilidad del IR de acuerdo con los cuartiles de vaspina para la muestra, con respecto al sexo. Resultados: la vaspina se correlacionó positivamente con IR en adolescentes con alto %CG (r = 0,23; p = 0,003). El análisis de regresión logística ajustada por sexo, edad, índice de masa corporal y etapa puberal mostró que los adolescentes en el segundo (OR = 0,43; IC del 95% = desde 0,23 hasta 0,80, p = 0,008) y tercer (OR = 0,46; IC del 95% = 0,25-0,85, p = 0,014) cuartil de concentración de vaspina tenían un menor riesgo de IR. Cuando el modelo se ajustó para %GC y actividad física, la asociación siguió siendo estadísticamente significativa solo para los adolescentes en el segundo cuartil. Conclusión: la vaspina se correlacionó positivamente con los factores de riesgo asociados con el metabolismo de la insulina en los adolescentes con alto %GC. Asimismo, se asoció con un menor riesgo de IR independientemente del índice de masa corporal y de etapa de la pubertad, y la asociación estuvo influenciada por la grasa corporal y la actividad física en estos adolescentes (AU)